The O. Henry Playhouse was an early American anthology television series which featured television adaptations of short stories written by 19th-century author O. Henry and primarily set in New York City. The series was both hosted and narrated by Thomas Mitchell, who portrayed the title character, and featured several television and film stars during its run such as DeForest Kelley, Lisa Montell, Otto Kruger, Max Showalter and Ernest Borgnine. The series was syndicated and initially ran from January 23 to May 25, 1957, and its final episode aired on November 19 of that year.

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